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June 29, 2017

The past few weeks have been thrilling to say the least; it is always amazing learning new things and I am glad this INBRE experience has been as enlightening as I hoped it would be. It has given me a chance to hone research skills such as patience, diligence, observation, deduction and so much more.

 

I am still floored by the vast amount of information and have been spending the last few weeks reading different science articles from others in the channelopathy field so as to get a better handle on my project. The current mutation I am characterizing is a missense mutation which replaces arginine with tryptophan in the first domain of a sodium channel. While certain trends I have observed are expected, the current results also goes against previously established hypotheses.

 

We are hoping to use molecular dynamics which will allow us observe the mutation in a simulated sodium channel and determine how its interactions with its surroundings cause results to differ from the expected and if this behavior conforms to the recent hypothesis formulated. I am looking forward to analyzing even more of my data.

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